The secretion of interferon gamma (IFN‐γ), interleukin (IL)−12, and tumor necrosis factor (TNF)‐α secreted by T helper (Th) 1 cells orchestrates macrophage‐mediated infection resistance, osteoclastogenesis induction, and fibrogenesis promotion.[10] Conversely, Th2 cells secrete IL‐4, IL‐10, and IL‐13, which prevent bone destruction and promote bone healing.[11] Therefore, creating an immune microenvironment that eliminates Th1 while promoting Th2 polarization at the site of the defect may block the pro‐inflammatory reaction and promote osteogenesis.[10, 11, 12]. The gene discussed is TNF; the disease is infection.