SOD2 and allergic asthma: OXPHOS exerted a negative regulatory effect on Th1‐related functions, while the inhibition of Th2 responses in an allergic asthma model is observed as a result of abnormalities in OXPHOS.[16] The metabolic processes of glutamine and glycolysis have been found to facilitate the synthesis of IFN‐γ by Th1 cells.[17] The augmentation of Th2 cell responses is facilitated by the accumulation of adenosine triphosphate (ATP) and the process of fatty acid oxidation.[18] Manganese superoxide dismutase (MnSOD), stationed within mitochondria, assumes a cardinal role in energy metabolism.