In addition to reductions in the amounts of RanBP2 associating with other nucleoporins, Hofemeister and O’Hare also noted lower levels of O-glycosylated RanBP2 in HSV-1 infected cells and suggested that alterations in the post-translational modification of pore components during infection might influence nucleocapsid/NPC interactions late in infection [69]. This evidence concerns the gene NPC1 and infection.