We found that AKT1 hypermethylation was not associated with serum biochemical indicators in AD (S1 Fig, p > 0.05), and MAP2K1 hypomethylation was negatively correlated with serum TG levels in the MCI female group (S2 Fig, p = 0.0084, r = -0.58). This evidence concerns the gene MAP2K1 and Alzheimer disease.