It showed that ADCY2 didn’t have significantly different expressions in the brain between AD and normal people (Fig 2, p > 0.05), while AKT1 had significantly different expressions in Entorhinal Cortex and MAP2K1 had significantly different expressions in Entorhinal Cortex, Temporal Cortex, Hippocampus and Frontal Cortex in AD (Fig 2, p < 0.05). This evidence concerns the gene ADCY2 and Alzheimer disease.