Ceramide generated by nSMase or exogenously added ceramide analogs have been reported to potently activate the expression of the fibroblast’s MMP-1 (Collagenase-1) that degrades collagens types I, II, and III [125], the predominant collagen isotypes associated with egg granuloma in schistosomiasis [126,127]. Here, MMP1 is linked to schistosomiasis.