GRS for T2D was associated with severe autoimmine diabetes, severe insulin deficient diabetes, mild obesity-related diabetes, mild age-related diabetes but not with severe insulin resistant diabetes (which is the cluster with highest incidence of CKD, macroalbuminuria, ESRD); GRS for insulin secretion was associated with mild obesity-related diabetes, mild age-related diabetes and severe insulin deficient diabetes; GRS for insulin resistance was not associated with any cluster. This evidence concerns the gene INS and chronic kidney disease.