As [18F]FDG tumor uptake in the firstminutes provides a reliable measure of blood flow,61 we conclude that the observed specific tumor uptake of[64Cu]Cu-3 indeed reflects PD-L1 binding.Clearance of [64Cu]Cu-3 was similar to that of [64Cu]Cu-1 due to the same substitution patternof hydrophilizing units; however, it was slightly more via the renalroute. Here, CD274 is linked to neoplasm.