MEN1 and parathyroid gland adenoma: In another study of parathyroid tissue, menin loss was reported to be associated with increased DNA methylation, a DNA mark associated with transcriptional repression [38] and 12 human MEN1-associated and one sporadic parathyroid adenoma with a L338P missense MEN1 mutation were found to have increased global DNA methylation when compared to twelve sporadic parathyroid adenomas with no MEN1 gene mutations and nine normal parathyroid tissue samples [38].