POU5F1 and neoplasm: Moreover, we observed and calculated the number of OCT4/SOX2/NANOG/FOXP3 positive cells per area taken from sections of the tumor tissues (Fig. 1C), and consequently found similar trend in stemness genes and FOXP3 coincides with high-grade of breast tumor compared to low-grade breast tumor (p < 0.0001) (Fig. 1D).