At baseline, most patients were Barcelona Clinic Liver Cancer (BCLC) Stage A (5 patients) with median alpha fetoprotein (AFP) level ≤ 400 μg/L (6 patients), and all patients were Child Pugh (A) Three patients had a history of hepatitis C and 1 patient had a history of hepatitis (B) No patients had received prior systemic therapy, but 4 patients received prior local therapies, consisting of lobectomy, radiofrequency ablation, ethanol ablation, transarterial chemoembolization (TACE), and selective internal radiation therapy (SIRT). The gene discussed is AFP; the disease is liver cancer.