It is noteworthy that our pooled estimates, which stem form data of non-East Asian studies, are in line with those obtained in the East Asian subgroup of stroke/TIA patients from the previous meta-analysis of Pan et al. [16], which found that East-Asian carriers of CYP2C19 LOF alleles are at higher risk of stroke in comparison with non-carriers (RR: 1.93, 95%CI 1.55–2.39, P < 0.00001), while no difference emerged among patients of East Asia in the risk of bleeding (RR: 0.92, 95%CI: 0.58–1.45, P = 0.72). This evidence concerns the gene CYP2C19 and Stroke.