The activation of TLRs signaling pathway, particularly TLR2 and TLR4, by their ligands, such as bacterial products and damage-associated molecular patterns (DAMPs), was found to promotes ovarian cancer cell invasion through the induction of matrix metalloproteinases (MMPs) and the activation of the NF-κB signaling pathway [68]. The gene discussed is NFKB1; the disease is ovarian cancer.