CD8A and viral infectious disease: Moreover, the production of innate immunostimulatory molecules such as IL-6 that are produced during the acute phase of viral infection outweigh negative regulatory effects of nitric oxide synthase 2–dependent production of nitric oxide (Lukacs-Kornek et al., 2011), augmenting virus-specific CD8+ T cell memory responses including differentiation into tissue-resident memory T cells (Brown et al., 2019).