The cell proliferation marker MKI67 as well as genes involved in G1-S and G2-M transition, such as CDK1, CDK2, CCNE2, PRIM2, AKT1, and FOXM1, were significantly downregulated in latent infection compared to actively infected cells (Fig. 4G). This evidence concerns the gene MKI67 and disease arising from reactivation of latent virus.