The cell proliferation marker MKI67 as well as genes involved in G1-S and G2-M transition, such as CDK1, CDK2, CCNE2, PRIM2, AKT1, and FOXM1, were significantly downregulated in latent infection compared to actively infected cells (Fig. 4G). The gene discussed is PRIM2; the disease is disease arising from reactivation of latent virus.