In uninfected cells, SEC13 was localized in the ER, in COPII vesicles (Sec23), and cis-Golgi and less in the nucleus.(Fig. 3) After 8h of infection, SEC13 did not increase in the nucleus but was more evident in the cis-Golgi and less in the COPII vesicles, while at 16 h, it was significantly enhanced in the ER. The gene discussed is SEC13; the disease is infection.