SEPTIN7 and mesothelioma: Septin 7 has also been identified as a factor that binds to the CALB2 promoter region, resulting in decreased calretinin expression in mesothelioma cell lines.24 Septin 7 is a GTP-binding protein that is involved in cytokinesis, cytoskeleton organization and other cellular processes.24,55 It was also implicated in calcium homeostasis.56 Several studies also reported that septin 7 plays an important role in cancer development, especially glioma.55,56 In our study, SEPTIN7 rs3801339 was not significantly associated with MM susceptibility or with serum calretinin levels.