E2F2 and cancer: E2F2 has an important role in the regulation of cell cycle, but also affects other important processes such as cell proliferation, apoptosis and inflammation.42 In cancer, it was mostly associated with promoting tumor progression in various malignancies, including lung cancer.42 E2F2 could also contribute to the cell cycle-dependent differences observed for calretinin expression.23E2F2 rs2075995 is a nonsynonymous SNP and may influence splicing.