Furthermore, we also undertook the first CSF-based single-cell expression quantitative trait loci (eQTL) analysis, which identified eQTL effects for two multiple sclerosis susceptibility variants in CD8+ T cells, the risk allele rs10271373_A increasing expression of the zinc finger CCCH-type antiviral protein 1 (ZC3HAV1) and rs1059091_A reducing the expression of interferon-induced transmembrane protein 2 (IFITM2). This evidence concerns the gene CD8A and multiple sclerosis.