CD8A and multiple sclerosis: Our eQTL analysis indicates that the multiple sclerosis susceptibility variant rs10271373 influences the expression of ZC3HAV1 in CD8+ T cells, a gene with four isoforms,61 two of which, ZAP-L and ZAP-S,62 are suggested to be important in resistance to particular viruses.62-65 This eQTL effect appears to be driven by an underlying splicing QTL, with increased usage of the ZAP-L isoform in individuals that carry the multiple sclerosis risk allele (rs10271373_A).