At a FDR of <10%, using linear regression and permutation-based statistics, we identified three multiple sclerosis-associated factors: factor 9 in CD4+ T cells, factor 3 in macrophages and factor 7 in macrophages and dendritic cells (Fig. 2B), the top-weighted genes for each factor are shown in Fig. 2C. This evidence concerns the gene CD4 and multiple sclerosis.