Deciphering the ATRX-independent roles of DAXX may hold the key to uncovering critical functions perturbed in DAXX-overexpressing cancers, as well as in cancers harboring DAXX mutations such as PanNETs (94,95) and pediatric high-grade gliomas (pHGGs) (36), while also providing novel therapeutic strategies for such cancers. Here, ATRX is linked to cancer.