To further validate our findings in human cancers, we analyzed protein expression levels of ATXN3, PD-L1, IRF1, and HIF-2α in human lung adenocarcinoma tissue microarrays and melanoma tissue microarrays, which included 61 lung adenocarcinoma cases and 48 melanoma cases, respectively. The gene discussed is CD274; the disease is lung adenocarcinoma.