Further analysis of tumor-infiltrating CD8+ T cells revealed a less exhausted phenotype, with a significant reduction in the fraction of Tim3+, LAG3+, Blimp1+, and EOMES+ as well as annexin V+ CD8+ T cells (Figure 4, K–N and Q), but with a modest increase in T-bet+ cells (P = 0.1878) and CD44+CD8+ T cells (Figure 4, O and P). This evidence concerns the gene LAG3 and neoplasm.