IRF1 and cancer: However, unlike IRF1 and STAT3 coexpression that fully rescued IFN-γ–induced PD-L1 expression (Supplemental Figure 5A), HIF-2α expression could not rescue ATXN3-KO cancer cell expression of PD-L1 when cultivated under hypoxia conditions, nor when IFN-γ was added, suggesting that additional genes are involved in the hypoxia/ATXN3/HIF-2α pathway to control hypoxia-induced PD-L1 expression on cancer cells.