The most common TRAEs (≥20%) were hyperglycemia (16 [88.9%]), weight loss (11 [61.3%]), elevated insulin C‐peptide (6 [33.3%]), diarrhea (6 [33.3%]), elevated alanine aminotransferase (5 [27.8%]), elevated aspartate aminotransferase (5 [27.8%]), elevated blood insulin (5 [27.8%]), hypokalemia (5 [27.8%]), decreased appetite (5 [27.8%]), hypocalcemia (5 [27.8%]), nausea (5 [27.8%]), vomiting (5 [27.8%]), hypoalbuminemia (4 [22.2%]), hyponatremia (4 [22.2%]), sinus bradycardia (4 [22.2%]), urinary tract infection (4 [22.2%]), rash (4 [22.2%]), and proteinuria (4 [22.2%]) (Table 2). This evidence concerns the gene INS and Hyperglycemia.