We have previously evaluated 300 community-based individuals chosen for equal representation among ethnic groups divided into four groups based whether positive (POS) or negative (NEG) for plasma P-tau 217 and P-tau 181 concentrations that discriminated AD pathology2, and whether symptomatic (Sym) or asymptomatic (Asym) for mild cognitive impairment (MCI) or dementia. The gene discussed is MAPT; the disease is Alzheimer disease.