In PDO15 dataset, tumor cells highly recapitulated the cell populations described by Riemondy et al (2022) in Group 3 medulloblastoma samples: B1 (enriched with neural progenitor markers), C1 (characterized by high levels of DST and CADPS, involved in the RNA processing) and C2 (showing high levels of factors involved in phototransduction mechanisms, such as GNGT1, CABP5, and IMPG2) (Fig 4C and D). The gene discussed is GNGT1; the disease is medulloblastoma.