Other clusters of cells with tumor‐associated functions included: undifferentiated/progenitor cells with “neuronal stem‐like” gene signature (STMN2/4, SOX2, TUBB/TUBB3, PAX3/6‐positive); cells with prominent metabolic functions (GAPDH, VEGFA, IGFBP5, NDUFA4L2); cells with an active proliferative phenotype (PLK1, Ki67, TOP2A, CENPF) (Fig EV5C and D). The gene discussed is IGFBP5; the disease is neoplasm.