Spinal cord injury (SCI) is a severe form of central nervous system (CNS) damage that leads to significant neurological dysfunction due to disruption of neural circuitry.[1] The post‐SCI pathophysiological progression involves an immune response.[2] CD4+ T cells are important components of the immune response following an injury, and the balance between different subtypes of CD4+ T cells is crucial for neuroprotection.[3]. This evidence concerns the gene CD4 and spinal cord injury.