This limitation of RDT detection for low parasitemia [26] would explain the false-negative cases observed in our study, although other factors have been listed by other authors including the lack of specificity of the monoclonal antibodies used to design RDTs, the genetic diversity of the HRP2 parasite antigen, or the deletion of the gene-coding HRP2 [27]. This evidence concerns the gene HDGFL2 and parasitic infectious disease.