Erbin protects against sepsis-associated encephalopathy by attenuating microglial pyroptosis via the IRE1α/Xbp1s-Ca2+ axis [12], and NLRP3/Caspase-1 pathway-induced pyroptosis mediates cognitive deficits in a mouse model of sepsis-associated encephalopathy [13]. The gene discussed is ERN1; the disease is Sepsis.