HBB and sickle cell disease: In summary, we observed a predicted LOF variant in the HBB gene, p.Glu7Lys (rs33930165), demonstrating associations with hereditary hemolytic anemias and sickle cell anemia (phecodes = 282 and 282.5, odds ratios [OR] = 5.63 and 6.59, P = 1.26 × 10−13 and 2.8 × 10−11).