PSEN1 and dementia: Additionally, a predicted LOF variant in PSEN1, p.Gly206Ala (rs63750082), exhibited an association with dementias (phecode = 290.1, OR = 17.3, P = 9.79 × 10–10), while a neutral variant in PSEN1, p.Glu318Gly (rs17125721), did not demonstrate such an association (P = 0.86).