Both ESR (continuous variable) and CRP levels above 75th percentile (> 12 mg/l) at 2 years showed robust associations with subsequent CAD in crude as well as in models adjusted for age, sex and hypertension [adjusted HR per SD 1.48; 95% CI 1.16–1.88, and adjusted HR 2.33; 95% CI 1.27–4.28 respectively]. This evidence concerns the gene ESR1 and Hypertension.