All the SU5416, BHGZD and the two-BACs-combination interventions significantly decreased VEGF and NO content, and the enzymatic activity of eNOS in the supernatant of MH7A cells, and reduced the ratios of p-VEGFR2/VEGFR2, p-SRC/SRC, p-PI3K/PI3K and p-AKT/AKT in VEGF-induced HUVEC cells, all of which suggesting that both BHGZD and the two-BACs-combination may inhibit synovial vascularization in RA by interfering with the VEGFA/VEGFR2/SRC/PI3K/AKT signal axis (Fig. 7). Here, NOS3 is linked to rheumatoid arthritis.