VEGFA and rheumatoid arthritis: Functional enrichment analysis was performed on the above core node genes, and we found that BHGZD key network targets were significantly involved in regulating vascular neovascularization-related pathways, such as platelet activation, complement and coagulation cascades, HIF-1 signaling pathway, hematopoietic cell lineage, VEGF signaling pathway and etc., suggesting that BHGZD may have a potential to intervene with synovial vascular neovascularization in RA.