PPARA and hypertrophic cardiomyopathy: In addition, the KEGG analysis showed that the proteins that were specifically downregulated in the LA were enriched in tight junction and hypertrophic cardiomyopathy, those in the IVS were enriched in pyruvate metabolism and carbon metabolism, those in the LV were enriched in pyruvate metabolism and carbon metabolism, those in the RA were enriched in focal adhesion and the PPAR signaling pathway, and those in the RV were enriched in biosynthesis of amino acids and cysteine and methionine metabolism (Fig. 1G).