However, overexpression of GSTM2 by AAV9-GSTM2 infection notably alleviated DNA damage, as evidenced by decreased γ-H2AX expression in PE-treated cardiomyocytes (Fig. 6G) and inhibiting of 8-OHDG production (Fig. 6H) and eccDNA release in mouse HF samples (Fig.  6I). Here, H2AX is linked to hydrops fetalis.