CD8A and neoplasm: Notarangelo et al. recently reported that D-2-hydroxyglutarate (D-2HG), a metabolite of tumors with mutated isocitrate dehydrogenase (IDH), impairs CD8+ T cell mediated tumor cell cytotoxicity. Overaccumulation of D-2HG in TME would inhibit lactate dehydrogenase (LDH) activity and glucose metabolism, thus damage the activation, proliferation and cytotoxicity CD8+ T cells [146].