SLC19A2 and thiamine-responsive megaloblastic anemia syndrome: Thiamine-Responsive Megaloblastic Anemia syndrome (TRMA, OMIM:249270), also named Rogers syndrome [1], is an autosomal recessive disease caused by loss-of-function mutations in the SLC19A2 gene (chromosome 1q23.3), which encodes the human thiamine transporter 1 (h-THTR1) protein, the main transporter of thiamine in many tissues.