Our data showed that metastatic LC cells managed to survive and proliferate in the lung parenchyma by upregulating SCEL expression to enhance TNF-α/TNFR1-mediated NF-κB /c-FLIP survival pathway and Akt/Erk1/2 growth signaling. This evidence concerns the gene TNFRSF1A and laryngotracheoesophageal cleft.