Given that our data showed that SCEL depletion significantly impaired 3D colony-forming ability, suppressed in vivo lung colonization capability and blocked TNF-α-induced NF-κB pro-survival signals of LC cells, we inquired about whether SCEL depletion could switch TNF-α-induced cell survival to apoptosis in the TNBC cells. Here, TNF is linked to laryngotracheoesophageal cleft.