LGR5 and breast cancer: Oskarsson et al. showed that disseminated breast cancer cells could express tenascin C (TNC) to promote the survival and outgrowth of lung micrometastases by enhancing the expression of musashi homolog 1 (MSI1) and leucine-rich repeat-containing G protein-coupled receptor 5 (LGR5) to activate NOTCH (Neurogenic locus notch homolog protein 1) signaling and WNT pathway, respectively [32].