Based on an analysis of 30 human cancers, ATP7B expression was related to immunostimulatory activity, including ESCA(HHLA2:rho = 0.677, p < 2.2e-16; TNFRSF18:rho = -0.614, p < 2.2e-16) ( Fig. 17B). This evidence concerns the gene HHLA2 and cancer.