Our comprehensive elucidation of the role of Lrg1 in the progression of cerebral ischemia‒reperfusion injury based on scRNA-seq data indicates its ability to modulate of multiple cellular components within the brain, including perivascular cells, microglial cells, and endothelial cells, highlighting Lrg1 as a promising therapeutic target for the treatment of cerebral ischemia‒reperfusion injury. Here, LRG1 is linked to Cerebral ischemia.