Overall, we observed that compared to the sham-operated group, many types of cells in cerebral ischemia‒reperfusion injury brain tissue showed increased Lrg1 expression, suggesting that Lrg1 plays an important role in modulation of the cerebral ischemia‒reperfusion injury process and may be related to many cell types in the brain. The gene discussed is LRG1; the disease is brain ischemia.