LRG1 and brain ischemia: Lrg1 expression was observed in almost all the cell types of the cerebral ischemia‒reperfusion injury brain, including astrocytes, choroid plexus capillary endothelial cells, endothelial cells, ependymocytes, fibroblast-like cells, neural progenitor cells, macrophages, microglial cells, neurons, oligodendrocytes, pericytes, T cells, neutrophils, and vascular smooth muscle cells (Fig. 1D).