NFKB1 and neoplasm: Furthermore, recent studies [193] have demonstrated new mechanisms by which EVs promote lung metastasis: tumor-derived LC3 EVs activate lung fibroblasts to produce CCL2 via the HSP60-TLR2‐MyD88‐NF‐κB pathway, which can recruit Mos to the lungs, contribute to the formation of pulmonary PMN and ultimately promote metastasis.