AKT1 and central nervous system cancer: In another study [96], glioma cells selectively released tumor suppressive miR-3591-3p through EVs by targeting CBLB and activating the JAK2/PI3K/Akt/mTOR and STAT3 pathways to promote macrophage M2 polarization, and macrophages treated with miR-3591-3p mimics were enriched in TGFβ receptor signaling in EMT.