Furthermore, EV lnc-MMP2-2 upregulates EPB41L5 expression by sponging miR-1207-5p, and then EPB41L5 directly promotes endothelial-to-mesenchymal transition and destroys tight junctions, which ultimately promotes brain metastasis in NSCLC [215]. Here, EPB41L5 is linked to non-small cell lung carcinoma.