TJP1 and neoplasm: Mechanistically, EVs can be delivered into endothelial cells and then attenuate endothelial junction integrity by directly inhibiting the expression of vascular endothelial cadherin (VE-Cad), p120-catenin (p120) and zonula occludens-1 (ZO-1), which increase vascular permeability and promote tumor metastasis [125].