Among all AEs related to PD-1 inhibitor treatment, the highest incidence rate was 23% for hyperthyroidism and 22% for fatigue, followed by 17% for fever, 16% for anemia, 16% for AST increased, and finally, 12% for ALT increased, 12% for pruritus, 8% for rash, 8% for nausea, and 1% for pneumonia. The gene discussed is GPT; the disease is hyperthyroidism.