Same results were obtained in patients with age-related PDAC, where the rate of TP53 missense mutation was 50.9% in poor differentiated PDAC (vs. 40.0% in moderate and well differentiated PDAC, P = 0.021), as shown in Additional file 4: Table S6_Core Gene Pathway Alterations and Association with Tumor Differentiation in age-related KRASmut PDAC. This evidence concerns the gene TP53 and neoplasm.