TP53 and neoplasm: As shown in Additional file 4: Table S14_Core Gene Alterations and Association with Tumor Differentiation in KRASmut PDAC in the TCGA cohort, TP53 missense mutation was presented in 0 (0%) well differentiated tumors, while the rate was 54.0% in moderate differentiated tumors (P = 0.001) and 46.7% in poor differentiated tumors (P = 0.007).