TP53 and neoplasm: As shown in Additional file 4: Table S7_Multivariate Logistic Regression of Core Gene Pathway Alterations for Tumor Differentiation in KRASmut PDAC, TP53 missense mutation was the only alteration related to poor tumor differentiation in multivariate analysis (OR 1.848 [1.290–2.647], P = 0.001).