TP53 and neoplasm: Interestingly, however, the two pathways which may interlink with TP53 were also related to poor tumor differentiation (cell cycle: 20.4% in poor differentiated PDAC vs. 16.2% in others; Trithorax: 24.6% in poor differentiated PDAC vs. 20.0% in others) yet without significant differences, as shown in Table 1 and Additional file 4: Table S7_Multivariate Logistic Regression of Core Gene Pathway Alterations for Tumor Differentiation in KRASmut PDAC.