Indeed, we have reviewed the implications of both PGRN and GPNMB in NDs, including FTD, LSDs, PD, and AD, where they separately have been described to be biomarkers of disease and/or to directly contribute to crucial neurodegenerative processes, such as protein aggregation, neuroinflammation, and neuronal loss. The gene discussed is GRN; the disease is frontotemporal dementia.