In lung adenocarcinoma, the immune stemness genes Interleukin-6 (IL-6), Formyl peptide receptor 2 (FPR2) and Relaxin-3 (RLN3) can play an important role in tumor development through cytokine-cytokine receptor interactions and neuroactive ligand-receptor interactions [9]. This evidence concerns the gene RLN3 and lung adenocarcinoma.