FLT3 and leukemia: Interestingly, GNF-7 preferentially inhibited cell proliferation of FLT3-ITD-dependent leukemia cells (MOLM-13 and MV4-11) in a dose-dependent manner, whereas it has no apparent cytotoxic effect on leukemia cells with FLT3-WT (THP-1 and U937) in low dose concentration (Fig. 1A).