Kinase profiling revealed that GNF-7 not only evidently inhibited LYN, FYN, SRC, YES, BTK and CSK kinase that can also inhibited by dasatinib [24], but also inhibited ACK1 and mitogen-activated protein kinase (GCK) to kill NRAS-dependent cells in AML and acute lymphoblastic leukemia [25]. The gene discussed is TNK2; the disease is acute myeloid leukemia.