IL4 and chronic rhinosinusitis with nasal polyps: Notably, the distribution of H3K4me3 modifications exhibited a predominant focus on intergenic and promoter-TSS regions (Fig. 4a), and there were evident differences in the differential peaks in patients with Th2 CRSwNP compared with healthy controls, as well as in the IL-4 group compared with the IL-4 + BCI-121 group (Fig. 4b).