From a pathophysiological perspective, Th2 CRSwNP is notably characterized by local Th2 inflammation and immune dominance in the nasal mucosa, activation and recruitment of Th2 cells and of high local production of Th2 cytokines, including Interleukin (IL)-4, IL-5 and IL-13 [6–8]. This evidence concerns the gene IL4 and chronic rhinosinusitis with nasal polyps.