Multiple studies of community-based and clinical trial cohorts have clearly demonstrated that circulating biomarkers including hemodynamic stress (i.e., natriuretic peptides), inflammation (i.e., C-reactive protein), myocardial injury (i.e., cardiac troponin), and coagulation activity (i.e., D-dimer) improve risk prediction of AF incidence [4, 6, 7]. Here, CRP is linked to atrial fibrillation.