Emerging research suggests that specific inhibition of solTNF through chemical or medication interventions may induce anti-inflammatory responses while preserving innate immunity to infections like M.tb. XPro-1595, designed to exclusively inactivate solTNF, has demonstrated utility in animal models of central nervous system (CNS) diseases characterized by elevated TNF production, as well as in mitigating experimental arthritis [17] and endotoxin-induced liver damage without compromising innate immunity to infections [18]. The gene discussed is TNF; the disease is infection.