CXCR4 and tuberculosis: Treatment with Xpro-1595 reduced CXCR4 expression significantly as shown in Fig. 8C. Additionally, treatment with anti-TB drugs attenuated the level of CXCR4, which was further reduced in guinea pigs treated with the combination of anti-TB drugs and Xpro-1595 as shown in Fig. 8E F respectively when compared with guinea pigs M.tb infected controls (Fig. 8D).