Ma et al. [32] suggested that the effect of Aldh1a1-induced RA content on NAFLD depends on whether it activates retinoic acid receptors (RARs) or retinoic acid X receptors (RXRs), and that RARs and RXRs have opposite effects on lipid regulation. The gene discussed is ALDH1A1; the disease is metabolic dysfunction-associated steatotic liver disease.