Furthermore, familial adenomatous polyposis (FAP), which is similar to PJS, was found to have enriched Bacteroides fragilis and Bacteroides fragilis toxin (bft) in the colonic mucosa compared to healthy individuals, which increased the risk of faster tumor onset and greater mortality of colorectal cancer (CRC) [27]. This evidence concerns the gene PITX1 and Familial adenomatous polyposis.