For example, we observed shared subtypes that were depleted (for example, mt-Cytb+mt-Rnr2+ choroid plexus epithelial cell) or enriched (for example, Col25a1+Ndrg1+ interbrain and midbrain neuron) in both early- and late-onset AD mutant brains. The gene discussed is COL25A1; the disease is Alzheimer disease.