We used intravitreal injection of a recombinant viral vector (AAV2 4Y-F) to introduce a transgene comprising a ubiquitous promoter upstream of either a double-floxed inverse orientation (DIO) RodWT or Rod E122Q coding sequence into surviving inner retinal neurones in mice with advanced retinal degeneration (Pde6b rd1/rd1), expressing Cre-recombinase under the Grm6 promoter. Here, GRM6 is linked to retinal degeneration.