However, different experimental designs, including the administration of low-dose anti-TGF-β antibodies (0.3 mg/kg, 3/week, -1 to +4 weeks) or delayed treatment of high-dose anti-TGF-β antibodies (5 mg/kg, 3/week, +4 to +8 weeks) to Ang II-infused C57BL/6 mice, had no effect on aortic aneurysm or rupture in mice, even though serum TGF-β concentrations were reduced up to ~40% and 80%, respectively64. Here, TGFB1 is linked to aortic aneurysm.