Human plasma-derived EVs from AAA patients and control subjects exhibited differential protein profiles, and some proteins, such as ferritin, mitochondrial Hsp60, c-reactive protein, and platelet factor 4, which are involved in the main pathological mechanism of AAA, including oxidative stress, inflammation, and thrombosis, were detected in EVs in the plasma of AAA patients114. Here, PF4 is linked to triple-A syndrome.