ITPA and Alzheimer disease: These genes included Camkk1, Snd1, Metap1d, Dnal1, Rab15, Slc12a4, Nrd1, and Itpa. The upregulated genes in the WM of 3-month-old AD brains were associated with axonogenesis, gliogenesis, and ensheathment of neurons (Fig. 3d).