These genes, Thy1, Gfap, Tyrobp, Ctsd, Cst7, C1qb, Lyz2, Ctss, Trem2, Mpeg1, Hexb, Cd68, C1qb, C1qa, Ctsz, Grn, Laptm5, B2m, C1qc, Hexa, and Serpina3n, were increased in the 7-month-old 5XFAD model in the cortex and associated with amyloid plaque image patterns. This evidence concerns the gene CTSD and amyloidosis.