Although a direct link between BAP-1 and EZH2 has not been identified, clinical studies have shown that enhanced EZH2 expression is observed in renal clear cell carcinoma with lower BAP-1 expression and poor prognosis126, and loss of BAP1 function increases the efficacy of EZH2 inhibitors127,128. The gene discussed is EZH2; the disease is clear cell renal carcinoma.