DOT1L and neoplasm: In addition to the 8 representative PKMTs with tumor suppressor activity, PRDM16, MLL2, MLL4, SET domain bifurcated histone lysine methyltransferase 1 (SETDB1), SETD3, NSD1, NSD3, DOT1L, SUV39H1, and SUV39H2 have also been suggested to possess tumor suppressor activity138–146.