Notably, EZH2 frameshift (fs) or deletion (del) mutations represent prevalent mutation types that prompt EZH2 downregulation and consequent aberrant protein function in patients with myelodysplastic syndrome (EZH2 K718fs) and T-ALL (EZH2 fs; K405fs, L674fs, D183fs, L728fs, K61fs, C606Y, and Q570fs, EZH2 del;(7)(q35q36.1) 142.67-150.97, 142.03-157.56, 143.92-156.84, and 143.33-158.82 Mb) (Fig. 3d). Here, EZH2 is linked to acute lymphoblastic leukemia.