Finally, in CML, downregulation of PRDM2/RIZ expression is associated with promotion of cell proliferation, inhibition of apoptosis, and reduced differentiation, which are mediated by the dimethylation of H3K9 and subsequent suppression of the IGF-1 signaling pathway172. Here, PRDM2 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.