A meta-analysis suggested that the overexpression of NNT-AS1 was correlated with poor prognosis and advanced clinicopathologic characteristics in tumors57. AGAP2-AS1, a known cancer-related lncRNA activated by SP1 and RREB1, has been broadly upregulated in various types of tumors and correlated with the biological behaviors of cancer cells, including lung cancer58,59, breast cancer, gastric cancer60, pancreatic cancer61, hepatocellular cancer, esophageal cancer62, and ccRCC63. Here, RREB1 is linked to hepatocellular carcinoma.